Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride
DOI:
https://doi.org/10.22319/rmcp.v11i4.5192Keywords:
Hemoglobin, Lambs, Metabolites, Electrolytes, Zilpaterol hydrochlorideAbstract
This study aimed to evaluate zilpaterol hydrochloride (ZH, generic) supplementation on fattening hair sheep, using hematological and biochemical variables as health status indicators. A total of 32 hair lambs (Dorper x Pelibuey) were grouped by initial weight and randomly assigned into four treatments: T1= basal diet (control group), T2= basal diet supplemented with ZH at 0.10 mg·kg-1 of LW d-1 (Grofactor®, Virbac México, Guadalajara, Mexico), T3= basal diet supplemented with ZH at 0.20 mg·kg-1 of LW d-1, and T4= basal diet supplemented with ZH at 0.30 mg·kg-1 of LW d-1. Blood samples were collected on days 1, 15, and 30 of the study. The hematological profile was determined in fresh blood samples; metabolites, electrolytes, and hormones were determined in serum samples. The study followed a randomized complete block experimental design, using an orthogonal polynomial analysis to determine the trend of the responses at the different concentrations of ZH. Cholesterol and urea levels were higher (P<0.05) in T3 than in T2. Furthermore, the mean corpuscular hemoglobin concentration was higher (P<0.05) in T1 than in T3; the red blood cell distribution width was higher (P<0.05) in T2 and T3 than in T4. The Na levels and the number of platelets showed a linear trend (P <0.05) to decrease and increase, respectively, as ZH levels increased. A quadratic trend was observed (P<0.05) in mean corpuscular hemoglobin concentration and red blood cell distribution width with increasing dose of ZH (generic). The remaining variables did not show significant trends at ZH levels (generic). The values of the biochemical and hematological profiles were within the reference range, which suggests that the addition of ZH did not alter the health status of fattening lambs.
Downloads
References
Arteaga CJD. La industria ovina en México: Memoria 1er Simposium Internacional de Ovinos de Carne. Desafíos y oportunidades para la ovinocultura en México ante los nuevos esquemas de mercado abierto. Pachuca de Soto, Hidalgo. 2003.
Gastélum-Delgado MA, Avendaño-Reyes L, Álvarez-Valenzuela FD, Correa-Calderón A, Meza-Herrera CA, Mellado M, Macías-Cruz U. Circannual estrous behavior in Pelibuey ewes under arid conditions of Northwestern of Mexico. Rev Mex Cienc Pecu 2015;6(1):109-118.
Beermann DH. ASAS Centennial paper: A century of pioneers and progress in meat science in the United States leads to new frontiers. J Anim Sci 2009;87:1192-1198.
Avendaño-Reyes L, Macías-Cruz U, Álvarez-Valenzuela FD, Águila-Tepato E, Torrentera-Olivera NG, Soto-Navarro SA. Effects of zilpaterol hydrochloride on growth performance, carcass characteristics, and wholesale cut yield of hair-breed ewe lambs consuming feedlot diets under moderate environmental conditions. J Anim Sci 2011;89:4188-4194.
Partida-de-la-Peña JA, Casaya-Rodríguez TA, Rubio-Lozano MS, Méndez-Medina RD. Effect of zilpaterol hydrochloride on the carcass characteristics of Katahdin lamb terminal crosses. Vet Méx 2015;2(2):2448-6760.
López-Carlos MA, Ramírez RG, Aguilera SJ, Aréchiga CF, Méndez LF, Rodríguez H, Silva JM. Effect of ractopamine hydrochloride and zilpaterol hydrochloride on growth, diet digestibility, intake and carcass characteristics of feedlot lambs. Livest Sci 2010;131(1):23-30.
Estrada-Angulo A, Barreras-Serrano A, Contreras G, Obregón JF, Robles-Estrada JC, Plascencia A, Zinn RA. Influence of level of zilpaterol hydrochloride supplementation on growth performance and carcass characteristics of feedlot lambs. Small Ruminant Res 2008;80(1-3):107-110.
Frese DA, Reinhardt CD, Bartle SJ, Rethorst DN, Bawa B, Thomason JD, Loneragan GH, Thomson DU. Effect of ractopamine hydrochloride and zilpaterol hydrochloride on cardiac electrophysiologic and hematologic variables in finishing steers. J Am Vet Med Assoc 2016;249:668-677.
FDA. New Animal Drug Application (NADA) 141-258. ZILMAX (Zilpaterol Hydrochloride) type A medicated article for cattle fed in confinement for slaughter. Approval date: 10 August, 2006.
Arcella D, Baert K, Binaglia M, Gervelmeyer A, Innocenti ML, Ribo O, Steinkellner H, Verhagen H. Review of proposed MRLs, safety evaluation of products obtained from animals treated with zilpaterol and evaluation of the effects of zilpaterol on animal health and welfare. EFSA 2016;14(9):4579.
Loneragan GH, Thomson DU, Scott HM. Increased mortality in groups of cattle administered the β-Adrenergic agonists ractopamine hydrochloride and zilpaterol hydrochloride. PLoS ONE 2014;9(3):e91177.
García, E. Modificaciones al sistema de clasificación climática de Koeppen. 3ra. ed, México, DF. Instituto de Geografía. Universidad Nacional Autónoma de México, 1985.
NRC. Nutrient requirements of sheep. National Academy Press, Washington, DC, 1985.
SAS Institute Inc.2004. SAS/STAT® User’s Guide. Cary, NC: SAS Institute Inc.
Radostits OM, Gay CC, Blood DC, Hinchcliff KW. Clínica Veterinária: um tratado de doenças dos bovinos, ovinos, suínos, caprinos e eqüinos. 9th ed. Guanabara Koogan, Rio de Janeiro, 2002.
Kaneko JJ, Harvey JW, Bruss ML. Clinical biochemistry of domestic animals. 6th ed. San Diego (USA): Academic Press; 2008.
Vahedi V, Towhidi A, Zare –Shahneh A, Sadeghia M, Zamanic F, Dunshea FR. Effects of β-agonist zilpaterol hydrochloride feeding and supplementation period on growth and carcass characteristics of Lori-Bakhtiari lambs. Small Ruminant Res 2014;4672:4677.
Bibber-Krueger CLV, Miller KA, Parsons GL, Thompson LK, Drouillard JS. Effects of zilpaterol hydrochloride on growth performance, blood metabolites, and fatty acid profiles of plasma and adipose tissue in finishing steers. J Anim Sci 2015;93:2419-2427.
Hatefi A, Towhidi A, Zali A, Zeinoaldini S, Ganjkhanlou M, Plascencia A. Effects of dietary zilpaterol hydrochloride (β2-agonist) supplementation on finishing castrated male goats: metabolic endocrine, blood constituents, plasma volume, respiratory rate and cardiac changes. J Appl Anim Res 2017;45(1):447-453.
Zimmerli U, Blum J. Acute and longterm metabolic, endocrine, respiratory, cardiac and skeletal muscle activity changes in response to perorally administered β‐adrenoceptor agonists in calves. J Anim Physiol Anim Nutr 1990;63:157-172.
Nourozi M, Abazari M, Raisianzadeh M, Mohammadi M, Zare-Shahne A. Effect of terbutaline and metaproterenol (two beta-adrenergic agonists) on performance and carcass composition of culled Moghani ewes. Small Ruminant Res 2008;74:72-77.
Chikhou FH, Moloney AP, Austin FH, Roche JF, Enright WJ. Effects of cimaterol administration on plasma concentrations of various hormones and metabolites in Friesian steers. Domest Anim Endocrinol 1991;8:471-480.
Buntyn JO, Steffen D, Burdick-Sanchez NC, Sieren SE, Jones SJ, Erickson GE, Carroll JA, Schmidt TB. Serum blood metabolite response and evaluation of select organ weight, histology, and cardiac morphology of beef heifers exposed to a dual corticotropin-releasing hormone and vasopressin challenge following supplementation of zilpaterol hydrochloride. J Anim Sci 2017;95:5327-5338.
Wagner A, Mostrom S, Hammer C, Thorson JF, Smith DJ. Adverse effects of zilpaterol administration in horses: three cases. J Equine Vet Sci 2008;28:238-243.
O’Connor RM, Butler WR, Finnerty KD, Hogue DE, Beermann DH. Acute and chronic hormone and metabolite changes in lambs fed the beta-agonist, cimaterol. Domest Anim Endocrinol 1991;8:537-548.
Dickson WM, Feldman EC, Hedge GA, Martin R, McDonald LE. Fisiología Veterinaria Cunningham. Cunningham JG editor. 3ra ed. Madrid, España: Elsevier; 2003.
Byrem TM, Beermann DH, Robinson TF. The beta-agonist cimaterol directly enhances chronic protein accretion in skeletal muscle. J Anim Sci 1998;76:988–998.
Shirato K, Tanihata J, Motohashi N, Tachiyashiki K, Tomoda A, Imaizumi K. β2-agonist clenbuterol induced changes in the distribution of white blood cells in rats. J Pharmacol Sci 2007;104:146-152.
Vicente-Pérez A, Avendaño-Reyes L, Barajas-Cruz R, Macías-Cruz U, Correa-Calderón A, Vicente-Pérez R, Corrales-Navarro JL, Guerra-Liera JE. Parámetros bioquímicos y hematológicos en ovinos de pelo con y sin sombra bajo condiciones desérticas. Ecosist Recur Agropec 2018;5(14):259-269.
Boyd BM, Shackelford SD, Hales KE, Brown-Brandl TM, Bremer TM, Spangler ML, et al. Effects of shade and feeding zilpaterol hydrochloride to finishing steers on performance, carcass quality, heat stress, mobility, and body temperature. J Anim Sci 2015;93:5801-5811.
Ahmadi-Hamedani M, Ghazvinian K, Atyabi N, Khanalizadeh P, Masoum MA, Ghodrati MS. Hematological reference values of healthy adult Sangsari sheep (Iranian fat-tailed sheep) estimated by Reference Value Advisor. J Appl Anim Res 2016;25:459-464.
Downloads
Published
How to Cite
-
Abstract671
-
PDF (Español)626
-
PDF212
-
Texto completo (Español)55
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
