Análisis in silico de genes diana de miRNAs posiblemente inducidos por la infección con tuberculosis

Autores/as

  • Elba Rodríguez-Hernández Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias. Centro Nacional de Investigación Disciplinaria en Fisiología y Mejoramiento Animal https://orcid.org/0000-0002-9551-7111
  • Laura Itzel Quintas-Granados Universidad Autónoma de la Ciudad de México. Colegio de Ciencias y Humanidades, Plantel Cuautepec. Ciudad de México, México. https://orcid.org/0000-0002-8622-2004
  • Feliciano Milian Suazo Universidad Autónoma de Querétaro https://orcid.org/0000-0003-4893-4868
  • Ana María Anaya Escalera Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias. Centro Nacional de Investigación Disciplinaria en Fisiología y Mejoramiento Animal

DOI:

https://doi.org/10.22319/rmcp.v15i1.6463

Palabras clave:

Mycobacterium, miR-146a, miR-146b, miR-155, predicción, diagnóstico

Resumen

El objetivo fue identificar mediante análisis in silico los genes a los cuales se unen los miR-146a, miR-146b y miR-155 y, analizar las rutas metabólicas en las que intervienen durante la infección con tuberculosis. Para el análisis se utilizó: miRBase, UniProtKB, TargetScan Human, miRDB y miRTarBase. El miR-146a interacciona o se une a genes importantes en la adhesión celular y el proceso de fagocitosis (CLDN16 y ATP6V1C2, respectivamente) (P, 0.05), esta interacción podría tener implicaciones importantes en la patogénesis de la tuberculosis o enfermedades relacionadas. Los resultados de este trabajo sugieren que la activación de mecanismos moleculares específicos en respuesta a la tuberculosis está regulada por los miR-146a, miR-146b y miR-155. Los genes con los cuales los miR-146a y miR-155 interaccionan o se unen, están involucrados en la respuesta inmune y en procesos celulares imprescindibles durante una infección por tuberculosis.

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Publicado

19.01.2024

Cómo citar

Rodríguez-Hernández , E., Quintas-Granados , L. I., Milian Suazo, F., & Anaya Escalera, A. M. (2024). Análisis in silico de genes diana de miRNAs posiblemente inducidos por la infección con tuberculosis. Revista Mexicana De Ciencias Pecuarias, 15(1), 192–207. https://doi.org/10.22319/rmcp.v15i1.6463
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