Efecto de la hesperidina añadida a las dietas de codorniz sobre los gases en sangre, la bioquímica sérica y HSP 70 bajo estrés por calor

Authors

  • Abdullah Özbilgin Sivas Cumhuriyet University Veterinary Faculty, Department of Animal Nutrition and Nutritional Disorders. Sivas, Turkey. https://orcid.org/0000-0002-1675-3176
  • Aykut Özgür Gaziosmanpaşa University. Artova Vocational School. Laboratory and Veterinary Health Program. Tokat, Turkey.
  • Onur Başbuğ Sivas Cumhuriyet University. Department of Veterinary Internal Medicine. Veterinary Medicine Faculty. Sivas, Turkey.

DOI:

https://doi.org/10.22319/rmcp.v14i4.6278

Keywords:

Flavonoide, Codorniz, Termoneutral, Proteína de choque térmico, Hesperidina

Abstract

El objetivo de este estudio fue determinar los efectos del flavonoide, que es un producto de la producción de cítricos, sobre los parámetros sanguíneos y la concentración de HSP70 en codornices aplicado en condiciones termoneutrales y de estrés por calor. En este contexto, 160 codornices (Coturnix coturnix japonica, macho), de 6 semanas de edad y 150-200 g de peso vivo, se alojaron en jaulas durante 1 semana de ejercicio y 5 semanas de período de ensayo. El diseño del estudio constó de 4 grupos de 40 animales y 4 subgrupos con 10 animales en cada grupo. La agrupación se realizó en forma de 2x2. Los grupos termoneutrales (24 ± 0.1 °C) son NC (0 g de hesperidina/kg de alimento base) y NHES3 (3 g de hesperidina/kg de alimento base) y los grupos bajo estrés por calor (34 ± 0.1 °C) son HC (0 g de hesperidina/kg de alimento base) y HHES3 (3 g de hesperidina/kg de alimento base), y se generaron aleatoriamente. En el caso de estrés por calor, las concentraciones de pO2, pH, HCO3 y Cl disminuyeron en el grupo HHES3 en comparación con el grupo HC (P<0.05). La concentración de enzimas ALP mostró una disminución significativa en el grupo HHES3 en comparación con el grupo HC en la condición de estrés por calor. El nivel de proteínas de choque térmico (Hsp70) aumentó en el suero sanguíneo, tejidos del riñón, hígado y pecho en el grupo HC con estrés celular durante el estrés por calor; sin embargo, la concentración de Hsp70 disminuyó significativamente en el grupo HHES3. Como resultado, se encontraron efectos positivos de la suplementación con hesperidina en la dieta tanto en condiciones de estrés por calor como en termoneutrales.

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References

Bartlett JR, Smith MO. Effects of different levels of zinc on the performance and immunocompetence of broilers under heat stress. Poult Sci 2003;82:1580–1588.

Attia YA, Bohmer BM, Roth-Maier DA. Responses of broiler chicks raised under constant relatively high ambient temperature to enzymes, amino acid supplementations, or a high-nutrient diet. Arch fur Geflugelkunde 2006;70:80-91.

Attia YA, Hassan RA, Tag El Din AE, Abou Shehema BM. Effect of ascorbic acid or increasing metabolizable energy level with or without supplementation of some essential amino acids on productive and physiological traits of slow growing chicks exposed to chronic heat stress. J Anim Physiol Anim Nutr (Berl) 2011;95:744-755.

Attia YA, Hassan SS. Broiler tolerance to heat stress at various dietary protein/energy levels. Eur Poult Sci 2017;81. DOI: 10.1399/eps.2017.171

Şahin K, Sahin N, Önderci M, Yaralioglu S, Kücük O. Protective role of supplemental vitamin E on lipid peroxidation, vitamins E, A and some mineral concentrations of broilers reared under heat stress. Vet Med 2001;46:140-144.

Attia YA, Abd El Hamid AEE, Abedalla AA, Berika MA, Al Harthi MA, Kucuk O, Abou Shehema BM. Laying performance, digestibility and plasma hormones in laying hens exposed to chronic heat stress as affected by betaine, vitamin C, and/or vitamin E supplementation. Springerplus 2016;5(1):1619.

Pardue SL, Thaxton JP, Brake J. Role of ascorbic acid in chicks exposed to high environmental temperature. J Appl Physiol 1985;58:1511-1516.

Siegel HS. Adrenals, stress and the environment. Worlds Poult Sci J 1971;27:327-349.

Siegel HS, Van Kampen M. Energy relationships in growing chickens given daily injections of corticosterone. Br Poult Sci 1984;25:477-485.

Ahmad T, Mushtaq T, Khan MA, Babar ME, Yousaf M, Hasan ZU, Kamran Z. Influence of varying dietary electrolyte balance on broiler performance under tropical summer conditions. J Anim Physiol Anim Nutr (Berl) 2009;93:613-621.

Borges SA, Fischer DA, Silva AV, Majorka A, Hooge DM, Cummings KR. Physiological responses of broiler chickens to heat stress and dietary electrolyte balance (sodium plus potassium minus chloride, milliequivalents per kilogram). Poult Sci 2004;83:1551-1558.

Olanrewaju HA, Purswell JL, Collier SD, Branton SL. Physiology, endocrinology, and reproduction. Effect of ambient temperature and light intensity on physiological reactions of heavy broiler chickens. Poult Sci 2010;89:2668-2677.

Pawar SS, Basavaraj S, Dhansing LV, Nitin KP, Sahebrao KA, Vitthal NA, Manoj BP, Kumar BS. Assessing and mitigating the impact of heat stress in poultry. Adv Anim Vet 2016;4:332–341.

John M. Functional morphology of the avian respiratory system, the lung-air sac system: efficiency built on complexity. Ostrich 2009;79:117–132.

Bongiovanni GA, Soria EA, Eynard AR. Effects of the plant flavonoids silymarin and quercetin on arsenite induced oxidative stress in CHO-K1 cells. Food Chem Toxicol 2007;45:971–976.

Akbarian A, Michiels J, Golian A, Buyse J, Wang Y, De Smet S. Gene expression of heat shock protein 70 and antioxidant enzymes, oxidative status, and meat oxidative stability of cyclically heat-challenged finishing broilers fed Origanum compactum and Curcuma xanthorrhiza essential oils. Poult Sci 2014;93:1930–1941.

Özgür A, Tutar Y. Heat shock protein 90 inhibition in cancer drug discovery: from chemistry to futural clinical applications. Anticancer Agents Med Chem 2016;16(3):280-290.

Tutar L, Tutar Y. Heat shock proteins; An overview. Curr Pharm Biotechnol 2010;11(2):216-222.

Tutar Y. Hsp70 in oncology. Recent Pat DNA Gene Seq 2011;5(3):214-218.

Li J, Fu X, Cao S, Li J, Xing S, Li D, Dong Y, et al. Membrane-associated androgen receptor (AR) potentiates its transcriptional activities by activating heat shock protein 27 (HSP27). J Biol Chem 2018;293:12719–12729.

Slimen IB, Najar T, Ghram A, Dabbebi H, Mrad MB, Abdrabbah M. Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review. Int J Hyperthermia 2014;30(7):513-523.

Quinteiro-Filho WM, Ribeiro A, Ferraz-de-Paula V, Pinheiro ML, Sakai M, Sa LR, Ferreira AJ, Palermo-Neto J. Heat stress impairs performance parameters, induces intestinal injury, and decreases macrophage activity in broiler chickens. Poult Sci 2010;89:1905-1914.

Tankson HD, Vizzier-Thaxton Y, Thaxton J, May J, Cameron J. Stress and nutritional quality of broilers. Poult Sci 2001;80:1384–1389.

Ahmad T, Khalid T, Mushtaq T, Mirza MA, Nadeem A, Babar ME, Ahmad G. Effect of potassium chloride supplementation in drinking water on broiler performance under heat stress conditions. Poult Sci 2008;87:1276-1280.

Syafwan S, Kwakkel RP, Verstegen MWA. Heat stress and feeding strategies in meat type chickens. Worlds Poult Sci J 2011;67:653-674.

Jain DP, Somani RS. Antioxidant potential of hesperidin protects gentamicin induced nephrotoxicity in experimental rats. Austin J Pharmacol Ther 2015;3:1071.

El-Shafey MM, Abd-Ellah GM. Hesperidin improves lipid profile and attenuates oxidative stress in hypercholesterolemic rats. Int J Pharm Sci 2014;4:554-559.

Kamboh AA, Hang SQ, Bakhetgul M, Zhu WY. Effects of genistein and hesperidin on biomarkers of heat stress in broilers under persistent summer stress. Poult Sci 2013;92:2411-2418.

Önderci M, Sahin K, Sahin N, Gürsu MF, Doerge D, Sarkar FH, Kücük O. The effect of genistein supplementation on performance and antioxidant status of Japanese quail under heat stress. Arch Anim Nutr 2004;58:463-471.

Laparra JM, Sanz Y. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol Res 2010;61:219-225.

Kamboh AA, Zhu WY. Effect of increasing levels of bioflavonoids in broiler feed on plasma anti-oxidative potential, lipid metabolites, and fatty acid composition of meat. Poult Sci 2013;92:454-461.

Özbilgin A, Kara K, Gümüş R, Tekçe E. Fatty acid compositions and quality of egg and performance in laying quails fed diet with hesperidin. Trop Anim Health Prod 2021;53:518.

Özbilgin A, Kara K, Urcar GS. Effect of hesperidin addition to quail diets on fattening performance and quality parameters, microbial load, lipid peroxidation and fatty acid profile of meat. J Anim Feed Sci 2021. https://doi.org/10.22358/jafs/143104/2021.

Özbilgin A, Moulko MN, Bayomendur FE, Ercan N. Effect of hesperidin supplementation on blood profile, antioxidant capacity, intestinal histomorphology and fecal microbial counts in Japanese quails. Rev Mex Cienc Pecu 2023;14(3):505-522.

Teeter RG, Belay T. Broiler management during acute heat stress, Anim Feed Sci Technol 1996;58:127–142.

N'dri AL, Mignon-Grasteau S, Sellier N, Beaumont C, Tixier-Boichard M. Interactions between the naked neck gene, sex, and fluctuating ambient temperature on heat tolerance, growth, body composition, meat quality, and sensory analysis of slow growing meat-type broilers. Livest Sci 2007;110:33–45.

NRC. Nutrient Requirements of Poultry. 9th ed. National Academy Press. Washington, DC. USA. 1994.

Shaila S, Angshuman S, Abhijeet K, Samindranath M, Pal JK. Flufenoxuron, an acylurea insect growth regulator, alters development of Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) by modulating levels of chitin, soluble protein content, and Hsp70 and p34cdc2 in the larval tissues. Pestic Biochem Physiol 2006;85(2):84-90.

Calder WA, Schmidt-Neilsen K. Temperature regulation and evaporation in the pigeon and road runner. Am J Physiol 1967;213:883–889.

Magda AAG. Some managerial and environmental conditions affecting on productive and physiological characters in quail. [PhD thesis]. Department of Animal Production, Cairo University. 1999.

Mahmoud UT, Abdel-Rahman M, Darwish MHA, Mosaad GM. The effect of heat stress on blood picture of japanese quail. J Adv Vet Anim Res 2013;3:69-76.

Özhan M, Tüzemen N, Yanar M. Büyükbaş hayvan yetiştirme. Atatürk Üniversitesi Ziraat Fakültesi Yayınları. Erzurum No:134. 2001;604.

Haddadin MSY, Abdulrahim MS, Hashlamoun EAR, Robinson KR. The effect of Lactobacillus acidophilus on the production and chemical composition of hen’s eggs. Poult Sci 1996;75:491-494.

Ajakaiye JJ, Perez-Bello A, Mollineda-Trujillo A. Impact of vitamins C and E dietary supplementation on leukocyte profile of layer hens exposed to high ambient temperature and humidity. Acta Vet Brno 2010;79:377-383.

Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3- L1 adipocytes. Diabetes 1998;47:1562-1569.

Kutlu HR, Forbes JM. Changes in growth and blood parameters in heat-stressed broiler chicks in response to dietary ascorbic acid. Livest Prod Sci 1993;36:335-350.

Rashidi AA, Ivari YG, Khatibjoo A, Vakilia R. Effects of dietary fat, vitamin E and zinc on immune response and blood parameters of broiler reared under heat stress. Res J Poult Sci 2010;3(2):32-38.

Mumma JO, Thaxton JP, Vizzier-Thaxton Y, Dodson WL. Physiological stress in laying hens. Poult Sci 2006;85:761–769.

Moeini MM, Bahrami A, Ghazi S, Targhibi MR. The effect of different levels of organic and inorganic chromium supplementation on production performance, carcass traits and some blood parameters of broiler chicken under heat stress condition. Biol Trace Elem Res 2011;144:715-724.

Mehaisen GMK, Desoky AA, Sakr OG, Sallam W, Abbas AO. Propolis alleviates the negative effects of heat stress on egg production, egg quality, physiological and immunological aspects of laying Japanese quail. PloS one 2019;14(4):e0214839.

Mujahid A, Akiba Y, Toyomizu M. Acute heat stress induces oxidative stress and decreases adaptation in young White Leghorn cockerels by down regulation of avian uncoupling protein. Poult Sci 2007;86:364-371.

Tan GY, Yang L, Fu YQ, Feng JH, Zhang MH. Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens. Poult Sci 2010;89:115-122.

Abdelhady DH, Elabasy MA, Atta MS, Ghazy EW, Abuzed TK, El-Moslumany A. Synergistic ameliorative effects of organic chromium and selenium against heat stress in japanese quails: performance, immunological, hematological, Biocheml Antioxidant Studies. AJVS 2017;55(2):113-123.

Al-Mashhadini T, Al-Hayali HL. Biochemical and physiological study of the effect of sesame seeds on quail males exposed to thermal stress. Indian J Public Health Res Dev 2020;11(4):1077-1083.

Al-Zeer AH, El-Hazmi MA, Wars AS, Ansari ZA, Yrkendi MS. Serum enzymes in heat stroke: prognostic implication. Clin Chem 1997;43(7):1182-1187.

Melesse A, Maak S, Schmidt R, von Lengerken G. Effect of long-term heat stress on key enzyme activities and T3 levels in commercial layer hens. Int J Livest Prod 2011;2(7):107-116.

Jaiswal SK, Raza M, Uniyal S, Chaturvedani AK, Sahu V, Dilliwar L. Heat stress and its relation with expression of heat shock proteins in poultry. Int J Environ Sci Technol (Tehran) 2017;6(1):159-166.

Erişir Z, Simsek UG, Özçelik M, Baykalır Y, Mutlu SI, Çiftci M. Effects of dietary grape seed on performance and some metabolic assessments in Japanese quail with different plumage colors exposed to heat stress. Rev Bras Zootec 2018;47:e20170172.

Şahin K. Optimal dietary concentration of vitamin E for alleviating the effect of heat stress on performance, thyroid status, ACTH and some serum metabolite and mineral concentrations in broilers. Czech J Anim Sci 2002;47(4):110-116.

Hosokawa N, Hirayoshi K, Nakai A, Hosokawa Y, Marui N, Yoshida M, et al. Flavonoids inhibit the expression of heat shock proteins. Cell Struct Funct 1990;15(6):393-401.

Budagova KR, Zhmaeva SV, Grigorev AN, Goncharova AY, Kabakov AE. Flavonoid dihydroquercetin, unlike quercetin, fails to inhibit expression of heat shock proteins under conditions of cellular stress. Biochem 2003;68:1055–1061.

Kim JA, Lee S, Kim DE, Kim M, Kwon BM, Han DC. Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter. Carcinogenesis 2015;36(6):696-706.

Xu J, Tang S, Song E, Yin B, Bao E. Inhibition of heat shock protein 70 intensifies heat-stressed damage and apoptosis of chicken primary myocardial cells in vitro. Mol Med Rep 2017;15(5).

Published

2023-10-02

How to Cite

Özbilgin, A., Özgür, A., & Başbuğ, O. (2023). Efecto de la hesperidina añadida a las dietas de codorniz sobre los gases en sangre, la bioquímica sérica y HSP 70 bajo estrés por calor. Revista Mexicana De Ciencias Pecuarias, 14(4), 836–854. https://doi.org/10.22319/rmcp.v14i4.6278
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