In vitro effect of furan acetamide bromide on Salmonellaenterica isolates from chickens

Abstract

Salmonella enterica subsp. enterica is one of the most interesting bacteria because of its pathogenic effect onanimals. The objective of the present study was to evaluate the in vitro effect of furan acetamide bromide (FAB) onavian Salmonella enterica. FAB was obtained from the Centro de Bioactivos Químicos of the Universidad Central delas Villas, Cuba. The antimicrobial activity of the product against Salmonella enterica isolates was determined by thebroth macrodilution method, according to the Committee for Clinical Laboratory Standards (NCCLS), document M7-A2. The minimum lethal concentration was determined by NCCLS, document M26-A, 1999. The biochemical andserological tests confirmed the presence of Salmonella gallinarum in 100 % of the samples. The minimum inhibitoryconcentration (MIC) and minimum bactericidal concentration (MBC) values of FAB were 12.5 μg/ml for Salmonellagallinarum and American Type Culture Collection (ATCC) of E. coli. It is concluded that MIC and MBC of Salmonellaenterica against in vitro effect of furan acetamide bromide was 12.5 μg/ml, demonstrating the antimicrobial activityof the product.