Ácidos hidroxicinámicos en producción animal: farmacocinética, farmacodinamia y sus efectos como promotor de crecimiento. Revisión
DOI:
https://doi.org/10.22319/rmcp.v10i2.4526Palabras clave:
Ácidos hidroxicinámicos, Rumiantes, Monogástricos, Farmacocinética, Farmacodinamia, Promotor de crecimientoResumen
El uso de aditivos de origen natural en producción animal ha tomado gran importancia en el sector pecuario, debido a su potencial de promover el crecimiento de una forma similar a los compuestos sintéticos como hormonas y antibióticos, pero sin causar posibles daños a la salud del animal, del consumidor o detrimento en la calidad de la carne. En los aditivos de origen natural existe una amplia variedad de compuestos, que son extraídos de distintas partes de las plantas, donde se toman ciertos aceites esenciales, mezclas de compuestos o compuestos aislados para utilizarse como remedios medicinales o suplementos alimenticios. Dentro de estos extractos, se encuentran los ácidos hidroxicinámicos, presentes en una gran variedad de vegetales, frutas y granos; los cuales presentan interesantes propiedades bioactivas como son, antioxidantes, antimicrobianos, preventivos de enfermedades cardiovasculares e inmunomoduladores. El uso de este tipo de aditivos en producción animal aún es limitado, pero se sugiere que su inclusión puede ser favorable como una estrategia para promover el crecimiento; sin embargo, dos aspectos importantes a estudiarse en los ácidos hidroxicinámicos es su farmacocinética y farmacodinamia, y a partir de allí establecer las condiciones de dosis, períodos de uso y efectos, además las posibles rutas y biotransformaciones que pueden ocurrir en el organismo animal. Esta revisión discute sobre la inclusión de ácidos hidroxicinámicos en dietas de animales de engorda, propiedades farmacocinéticas y farmacodinamias, y los hallazgos como promotores de crecimiento y sus efectos en la calidad de la carne.
Descargas
Citas
Mersmann HJ. Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci 1998;76(1):160-172.
Dávila-Ramírez JL, Avendaño-Reyes L, Macías-Cruz U, Torrentera-Olivera NG, Zamorano-García L, Peña-Ramos A, González-Ríos H. Effects of zilpaterol hydrochloride and soybean oil supplementation on physicochemical and sensory characteristics of meat from hair lambs. Small Rumin Res 2013;114(2):253-257.
Avendaño L, Torres V, Meraz F, Pérez C, Figueroa F, Robinson P. Effects of two b-adrenergic agonists on finishing performance, carcass characteristics, and meat quality of feedlot steers. J Anim Sci 2006;84:3259-3265.
Vallejos A, Zaragoza JC, Parres JA. Intoxicación por clembuterol”, Sistema Nacional de Vigilancia Epidemiológica. 2007;18:24.
Smith D. The pharmacokinetics, metabolism, and tissue residues of beta-adrenergic agonists in livestock. J Anim Sci 1998;76(1):173-194.
Pulce C, Lamaison D, Keck G, Bostvironnois C, Nicolas J, Descotes J. Collective human food poisonings by clenbuterol residues in veal liver. Vet Hum Toxicol 1991;33(5):480-481.
Kuiper H, Noordam M, van Dooren-Flipsen M, Schilt R, Roos A. Illegal use of beta-adrenergic agonists: European Community. J Anim Sci 1998;76(1):195-207.
Lopez-Romero JC, Ansorena R, Gonzalez-Aguilar GA, Gonzalez-Rios H, Ayala-Zavala JF, Siddiqui MW. In: Plant secondary metabolites, Vol 2: Stimulation, extraction, and utilization. Chap 5: Applications of plant secondary metabolites in food systems. 1rst ed. Waretown, NJ, USA: Apple Academic Press; 2016:195-232.
Gottlieb OR. Phytochemicals: differentiation and function. Phytochemistry 1990;29(6):1715-1724.
Meskin MS, Bidlack WR, Davies AJ, Omaye ST. Phytochemicals in nutrition and health.1rst ed. Florida, USA: Chemical Rubber Company press; 2002.
Alemanno A, Capodieci G. Testing the limits of global food governance: the case of ractopamine. Eur J Risk Regul 2012;(12):400-407.
Patra AK, Saxena J. Dietary phytochemicals as rumen modifiers: a review of the effects on microbial populations. Antonie Leeuwenhoek 2009;96(4):363-375.
Chen JH, Ho C-T. Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J Agric Food Chem 1997;45(7):2374-2378.
Scalbert A, Andres-Lacueva C, Arita M, Kroon P, Manach C, Urpi-Sarda M, Wishart D. Databases on food phytochemicals and their health-promoting effects. J Agric Food Chem 2011;59(9):4331-4348.
Jiang J, Xiong YL. Natural antioxidants as food and feed additives to promote health benefits and quality of meat products: A review. Meat Sci 2016;120:107-117.
Waghorn GC, McNabb WC. Consequences of plant phenolic compounds for productivity and health of ruminants. Proc Nutr Soc 2003;62(02):383-392.
González-Ríos H, Dávila-Ramírez J, Peña-Ramos E, Valenzuela-Melendres M, Zamorano-García L, Islava-Lagarda T, Valenzuela-Grijalva N. Dietary supplementation of ferulic acid to steers under commercial feedlot feeding conditions improves meat quality and shelf life. Anim Feed Sci Technol 2016;222:111-121.
Labarca J. Nuevos conceptos en farmacodinamia: ¿debemos repensar cómo administramos antimicrobianos? Rev Chilena de Infectol 2002;19:S33-S37.
Niño-Medina G, Carvajal-Millán E, Lizardi J, Rascon-Chu A, Marquez-Escalante JA, Gardea A, Martinez-Lopez AL, Guerrero V. Maize processing waste water arabinoxylans: Gelling capability and cross-linking content. Food Chem 2009;115(4):1286-1290.
Maeda H, Dudareva N. The shikimate pathway and aromatic amino acid biosynthesis in plants. Annu Rev Plant Biol 2012;63:73-105.
Kroon PA, Williamson G. Hydroxycinnamates in plants and food: current and future perspectives. J Sci Food Agric 1999;79(3):355-361.
Razzaghi-Asl N, Garrido J, Khazraei H, Borges F, Firuzi O. Antioxidant properties of hydroxycinnamic acids: a review of structure-activity relationships. Curr Med Chem 2013;20(36):4436-4450.
Windisch W, Schedle K, Plitzner C, Kroismayr A. Use of phytogenic products as feed additives for swine and poultry. J Anim Sci 2008;86(Suppl 14):E140-E148.
Lafay S, Gil-Izquierdo A. Bioavailability of phenolic acids. Phytochem Rev 2008;7(2):301-311.
El-Seedi H, El-Said A, Khalifa S, Göransson U, Bohlin L, Borg-Karlson A-K, Verpoorte R. Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids. J Agric Food Chem 2012;60(44):10877-10895.
Asaff TA, De La Torre MM, Macias OR. Proceso para la recuperación de ácido ferúlico.. 2004. https:// 492 www.google.com/patents/WO2004110975A1?cl=en. Consultado Nov 8, 2016.
Crozier A, Jaganath IB, Clifford MN. Phenols, polyphenols and tannins: an overview. 494 Plant secondary metabolites: Occurrence, structure and role in the human diet. Oxford, 495 UK: John Wiley & Sons; 2006.
Rocha LD, Monteiro MC, Teodoro AJ. Anticancer properties of hydroxycinnamic acids-A Review. Canc Clin Onc 2012;1(2):109.
Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 2004;74(17):2157-2184.
Alam MA, Subhan N, Hossain H, Hossain M, Reza HM, Rahman MM, Ullah MO. Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutr Metab 2016;13(1):27.
Valenzuela-Grijalva NV, Pinelli-Saavedra A, Muhlia-Almazan A, Domínguez-Díaz D, González-Ríos H. Dietary inclusion effects of phytochemicals as growth promoters in animal production. J Anim Sci Technol 2017;59(1):8.
Hong J-C, Steiner T, Aufy A, Lien T-F. Effects of supplemental essential oil on growth performance, lipid metabolites and immunity, intestinal characteristics, microbiota and carcass traits in broilers. Livest Sci 2012;144(3):253-262.
Zhao Z, Moghadasian MH. Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies. Phytochem Rev 2010;9(1):133-145.
García-González R, López S, Fernández M, González JS. Effects of the addition of some medicinal plants on methane production in a rumen simulating fermenter (RUSITEC). Int Cong Series 2006;1293(0):172-175.
Busquet M, Calsamiglia S, Ferret A, Kamel C. Plant extracts affect in vitro rumen microbial fermentation. J Dairy Sci 2006;89(2):761-771.
Hashemi SR, Davoodi H. Herbal plants and their derivatives as growth and health promoters in animal nutrition. Vet Res Commun 2011;35(3):169-180.
Sørum H, Sunde M. Resistance to antibiotics in the normal flora of animals. Vet Res 2001;32(3-4):227-241.
Aarestrup FM, Jenser LB. Use of antimicrobials in food animal production. In: Simjee S. 528 foodborne diseases. Series Infectious Disease. Human Press Inc. Totowa NJ, USA. 529 2007:405-417.
Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003;78(3):517S-520S.
Li Y, Li L, Li J, Zhang L, Gao F, Zhou G. Effects of dietary supplementation with ferulic acid or vitamin E individually or in combination on meat quality and antioxidant capacity of finishing pigs. Asian-Australas J Anim Sci 2015;28(3):374.
Macías-Cruz U, Perard S, Vicente R, Álvarez F, Torrentera-Olivera N, González-Ríos H, Soto-Navarro S, Rojo R, Meza-Herrera C, et al. Effects of free ferulic acid on productive performance, blood metabolites, and carcass characteristics of feedlot finishing ewe lambs. J Anim Sci 2014;92(12):5762-5768.
Peña-Torres EF. Efecto de la suplementación de ácido ferúlico y ferulato de etilo en el comportamiento productivo y calidad de la carne de bovinos [tesis maestría]. Hermosillo, Sonora, México: Centro de Investigación en Alimentación y Desarrollo; 2014.
Herrera RH, Castillo MLA, Torres AJA. Methods to accelerate muscle development, 604 decrease fat deposits, and enhance feeding efficiency in pigs. Methods to accelerate 605 muscle development, decrease fat deposits, and enhance feeding efficiency in pigs. U.S. 606 patent published in February 24, 2011, Num 20110046224. 607 http:/www.faqs.org/patents/app/20110046224; 2009. Accessed Feb 26, 2017.
Gorewit R. Pituitary and thyroid hormone responses of heifers after ferulic acid administration. J Dairy Sci 1983;66(3):624-629.
Kopp C, Singh SP, Regenhard P, Müller U, Sauerwein H, Mielenz M. Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. Int J Mol Sci 2014;15(2):2906-2915.
Yang W, Ametaj B, Benchaar C, He L, Beauchemin K. Cinnamaldehyde in feedlot cattle diets: Intake, growth performance, carcass characteristics, and blood metabolites. J Anim Sci 2010;88:1082–1092.
Cardozo P, Calsamiglia S, Ferret A, Kamel C. Effects of alfalfa extract, anise, capsicum, and a mixture of cinnamaldehyde and eugenol on ruminal fermentation and protein degradation in beef heifers fed a high-concentrate diet. J Anim Sci 2006;84(10):2801-2808.
Chesson A, Stewart CS, Wallace RJ. Influence of plant phenolic acids on growth and cellulolytic activity of rumen bacteria. Appl Environ Microbiol 1982;44(3):597-603.
Borneman WS, Akin D, VanEseltine W. Effect of phenolic monomers on ruminal bacteria. Appl Environ Microbiol 1986;52(6):1331-1339.
Jung H-JG, Fahey GC, Merchen NR. Effects of ruminant digestion and metabolism on phenolic monomers of forages. Br J Nutr 1983;50(3):637-651.
Adam A, Crespy V, Levrat-Verny MA, Leenhardt F, Leuillet M, Demigné C, Rémésy C. The bioavailability of ferulic acid is governed primarily by the food matrix rather than its metabolism in intestine and liver in rats. J Nutr 2002;132(7):1962-1968.
Zhao Z, Moghadasian MH. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chem 2008;109(4):691-702.
Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131(1):66-71.
Li S, Huang K, Zhong M, Guo J, Wang WZ, Zhu R. Comparative studies on the interaction of caffeic acid, chlorogenic acid and ferulic acid with bovine serum albumin. Spectrochim Acta A Mol Biomol Spectrosc 2010;77(3):680-686.
Akin DE. Forage cell wall degradation and ρ-coumaric, ferulic, and sinapic acids. Agron J 1982;74(3):424-428.
Karre L, Lopez K, Getty KJ. Natural antioxidants in meat and poultry products. Meat Sci 2013;94(2):220-227.
Falowo AB, Fayemi PO, Muchenje V. Natural antioxidants against lipid–protein oxidative deterioration in meat and meat products: A review. Food Res Int 2014;64:171-181.
Chan W, Hakkarainen K, Faustman C, Schaefer D, Scheller K, Liu Q. Dietary vitamin E effect on color stability and sensory assessment of spoilage in three beef muscles. Meat Sci 1996;42(4):387-399.
Faustman C, Chan W, Schaefer D, Havens A. Beef color update: the role for vitamin E. J Anim Sci 1998;76(4):1019-1026.
Morrissey PA, Buckley DJ, Galvin K, Decker E, Faustman C, Lopez-Bote CJ. Antioxidants 636 in muscle foods: nutritional strategies to improve quality. Vitamin E and the oxidative 637 stabilities of pork and poultry. 1rst ed. USA: John Wiley & Sons; 2000:263-287.
Cox S, Gupta S, Abu-Ghannam N. Effect of different rehydration temperatures on the moisture, content of phenolic compounds, antioxidant capacity and textural properties of edible Irish brown seaweed. Food Sci Tech 2012;47(2):300-307.
Bloomberg BD, Hilton GG, Hanger KG, Richards CJ, Morgan JB, VanOverbeke DL. Effects of vitamin E on color stability and palatability of strip loin steaks from cattle fed distillers grains. J Anim Sci 2011;89(11):3769-3782.
Yang A, Lanari M, Brewster M, Tume R. Lipid stability and meat colour of beef from pasture-and grain-fed cattle with or without vitamin E supplement. Meat Sci 2002;60(1):41-50.
McDowell L, Williams S, Hidiroglou N, Njeru C, Hill G, Ochoa L, Wilkinson N. Vitamin E supplementation for the ruminant. Anim Feed Sci Technol 1996;60(3):273-296.
Brenes A, Viveros A, Goñí I, Centeno C, Sayago-Ayerdy S, Arija I, Saura-Calixto F. Effect of grape pomace concentrate and vitamin E on digestibility of polyphenols and antioxidant activity in chickens. Poult Sci 2008;87(2):307-316.
Cho J, Kim H, Kim I. Effects of phytogenic feed additive on growth performance, digestibility, blood metabolites, intestinal microbiota, meat color and relative organ weight after oral challenge with Clostridium perfringens in broilers. Livest Sci 2014;160:82-88.
Biquan Z, Lu C, Lianqiang C. Effects of phytogenic feed additives on growth performance, carcass, meat quality and pork antioxidative capacity in finishing pigs. J China Feed 2011;14:007.
Descalzo A, Sancho A. A review of natural antioxidants and their effects on oxidative status, odor and quality of fresh beef produced in Argentina. Meat Sci 2008;79(3):423-436.
Peña E, González-Ríos H, Islava T, Valenzuela-Melendres M, Peña-Ramos A, Zamorano L, Pinelli A, Dávila-Ramírez JL. 0896 Ferulic acid in diets of heifers and its effect on the oxidative stability of meat stored in refrigeration. J Anim Sci 2016;94 (Suppl 5):431-432.
Faustman C, Sun Q, Mancini R, Suman SP. Myoglobin and lipid oxidation interactions: Mechanistic bases and control. Meat Sci 2010;86(1):86-94.
Jiménez CIE, Martínez EYC, Fonseca JG. Flavonoides y sus acciones antioxidantes. Rev Fac Med UNAM 2009;52(2).
Soberon M, Cherney D, Cherney J. Free ferulic acid uptake in ram lambs. J Anim Sci 2012;90(6):1885-1891.
Soberon M, Cherney J, Liu R, Ross D, Cherney D. Free ferulic acid uptake in lactating cows. J Dairy Sci 2012;95(11):6563-6570.
Marcucci MC, Ferreres F, Garcıa-Viguera C, Bankova V, De Castro S, Dantas A, Valente P, Paulino N. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol 2001;74(2):105-112.
Crozier A, Del Rio D, Clifford MN. Bioavailability of dietary flavonoids and phenolic compounds. Mol Aspects Med 2010;31(6):446-467.
Aura AM. Microbial metabolism of dietary phenolic compounds in the colon. Phytochem Rev 2008;7(3):407-429.
Schoonmaker J. Novel feed additives for beef cattle. 76th Minnesota Nutrition Conference. Prior Lake, MN; 2015:130-142.
Flachowsky G, Lebzien P. Effects of phytogenic substances on rumen fermentation and methane emissions: A proposal for a research process. Anim Feed Sci Technol 2012;176(1–4):70-77.
Acamovic T, Brooker J. Biochemistry of plant secondary metabolites and their effects in animals. Proc Nutr Soc 2005;64(03):403-412.
Chen Y, Ma Y, Ma W. Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats. Eur J Drug Metab Pharmacokinet 2009;34(1):51-56.
Chesson A, Provan GJ, Russell WR, Scobbie L, Richardson AJ, Stewart C. Hydroxycinnamic acids in the digestive tract of livestock and humans. J Sci Food and Agric 1999;79(3):373-378.
Martin A. The origin of urinary aromatic compounds excreted by ruminants 2. The metabolism of phenolic cinnamic acids to benzoic acid. Br J Nutr 1982;47(01):155-164.
Kondo T, Ohshita T, Kyuma T. Comparison of phenolic acids in lignin fractions from forage grasses before and after digestion by sheep. Anim Feed Sci Technol 1994;47(3-4):277-285.
Besle J-M, Jouany J-P, Cornu A. Transformations of structural phenylpropanoids during cell wall digestion. FEMS Microbiol Rev 1995;16(1):33-52.
Lajoie MS, Cummings KR. Encapsulated dietary fatty acid salt products for ruminants. 566 Encapsulated dietary fatty acid salt products for ruminants. Google Patents; 1999. 567 https://www.google.com/patents/US5874102. Accessed Jun11, 2017.
Augustin MA, Sanguansri L, Lockett T. Nano‐and micro‐encapsulated systems for enhancing the delivery of resveratrol. Ann New York Acad Sci 2013;1290(1):107-112.
Wood T, Wallace R, Rowe A, Price J, Yáñez-Ruiz D, Murray P, Newbold C. Encapsulated fumaric acid as a feed ingredient to decrease ruminal methane emissions. Anim Feed Sci Technol 2009;152(1):62-71.
Soto L, Frizzo L, Avataneo E, Zbrun M, Bertozzi E, Sequeira G, Signorini M, Rosmini M. Design of macrocapsules to improve bacterial viability and supplementation with a probiotic for young calves. Anim Feed Sci Technol 2011;165(3):176-183.
Chandler TL, Fugate RT, Jendza JA, Troescher A, White HM. Conjugated linoleic acid supplementation during the transition period increased milk production in primiparous and multiparous dairy cows. Anim Feed Sci Technol 2017;224:90-103.
Gessner D, Ringseis R, Eder K. Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals. J Anim Physiol Anim Nutr 2016;1-24.
Turner AL, Shewry PR, Lovegrove A, Spencer JPE. Release of covalently bound 587 hydroxycinnamate, ferulic acid, from whole-grain. Proc Nutr Soc 2015;74: E113.
Kikuzaki H, Hisamoto M, Hirose K, Akiyama K, Taniguchi H. Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 2002;50(7):2161-2168.
Vasta V, Luciano G. The effects of dietary consumption of plants secondary compounds on small ruminant products quality. Small Rumin Res 2011;101(1):150-159.
Blanch M, Carro MD, Ranilla MJ, Viso A, Vázquez-Añón M, Bach A. Influence of a mixture of cinnamaldehyde and garlic oil on rumen fermentation, feeding behavior and performance of lactating dairy cows. Anim Feed Sci Technol 2016;219(Suppl C):313-323.
Li SY, Ru YJ, Liu M, Xu B, Péron A, Shi XG. The effect of essential oils on performance, immunity and gut microbial population in weaner pigs. Livest Sci 2012;145(1):119-123.
Kwon CH, Lee CY, Han SJ, Kim SJ, Park BC, Jang I, Han JH. Effects of dietary supplementation of lipid‐encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenic Escherichia coli. Anim Sci J 2014;85(8):805-813.
Zhang L, Li J, Yun TT, Li AK, Qi WT, Liang XX, Wang YW, Liu S. Evaluation of pilot-scale microencapsulation of probiotics and product effect on broilers. J Anim Sci 2015;93(10):4796-4807.
Jiao PX, Wei LY, Walker ND, Liu FZ, Chen LY, Beauchemin KA, Yang WZ. Comparison of non-encapsulated and encapsulated active dried yeast on ruminal pH and fermentation, and site and extent of feed digestion in beef heifers fed high-grain diets. Anim Feed Sci Technol 2017;228(Suppl C):13-22.
Meng QW, Yan L, Ao X, Zhou TX, Wang JP, Lee JH, Kim IH. Influence of probiotics in different energy and nutrient density diets on growth performance, nutrient digestibility, meat quality, and blood characteristics in growing-finishing pigs. J Anim Sci 2010;88(10):3320-3326.
Lees P, Cunningham F, Elliott J. Principles of pharmacodynamics and their applications in veterinary pharmacology. J Vet Pharmacol Ther 2004;27(6):397-414.
Fetoni AR, Mancuso C, Eramo SLM, Ralli M, Piacentini R, Barone E, Paludetti G, Troiani D. In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig. Neuroscience 2010;169(4):1575-1588.
Liu G, Wei Y, Wang Z, Wu D, Zhou A, Liu G. Effects of herbal extract supplementation on growth performance and insulin-like gro
Descargas
Publicado
Cómo citar
-
Resumen1304
-
PDF755
-
PDF 329
-
Texto Completo1101
Número
Sección
Licencia
Los autores/as que publiquen en la Revista Mexicana de Ciencias Pecuarias aceptan las siguientes condiciones:
De acuerdo con la legislación de derechos de autor, la Revista Mexicana de Ciencias Pecuarias reconoce y respeta el derecho moral de los autores/as, así como la titularidad del derecho patrimonial, el cual será cedido a la revista para su difusión en acceso abierto.
Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional.
