Linfadenitis caseosa: factores de virulencia, patogénesis y vacunas. Revisión

Autores/as

  • Maria Carla Rodríguez Domínguez Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México. https://orcid.org/0000-0002-1242-4455
  • Roberto Montes de Oca Jiménez Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México. https://orcid.org/0000-0002-0282-2660
  • Jorge Antonio Varela Guerrero Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México. https://orcid.org/0000-0001-6887-5979

DOI:

https://doi.org/10.22319/rmcp.v12i4.5699

Palabras clave:

linfadenitis caseosa, Corynebacterium pseudotuberculosis, factores de virulencia, patogénesis, vacunas

Resumen

La linfadenitis caseosa es una enfermedad que afecta la producción ovina y caprina a nivel mundial. El agente etiológico es una bacteria Gram positiva, intracelular facultativa denominada Corynebacterium pseudotuberculosis biovar ovis. La enfermedad puede cursar con un desarrollo cutáneo o visceral, provocando deterioro en la condición física del animal, así como pérdidas en la producción de leche y carne, decomiso de las canales, rechazo de las pieles y como consecuencia, grandes pérdidas económicas. El estudio de los factores de virulencia y los mecanismos de patogénesis han permitido comprender esta enfermedad, así como establecer las moléculas diana para el desarrollo de nuevas vacunas. Existen vacunas comerciales disponibles a nivel mundial; sin embargo, la protección conferida por éstas no ha sido eficaz en el control de la enfermedad. Actualmente el uso de nuevas tecnologías ha permitido la obtención y caracterización de proteínas con potencial inmunogénico para el desarrollado de nuevas vacunas, las cuales podrían ser una alternativa para incrementar la protección. En el presente trabajo se exponen los principales factores de virulencia de Corynebacterium pseudotuberculosis, sus implicaciones en la patogénesis y las tendencias actuales en las formulaciones vacunales.

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Biografía del autor/a

Maria Carla Rodríguez Domínguez, Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México.

Maria Carla Rodríguez Domínguez es  Licenciada en Microbiología: 2006-2011. Facultad de Biología, Universidad de la Habana, La Habana, Cuba. Fecha de obtención del Título: 4 de Julio 2011. También presenta titulo de Diplomado en Microbiología Veterinaria: 2014 - 2015. Consejo Científico Veterinario Cuba. Sociedad Cubana de Microbiología Veterinaria. La Habana. Cuba. Fecha de obtención de Título: 2015.

Actualmente es estudiante de ultimo semestre de Maestría en Ciencias Agropecuarias y Recursos Naturales. Facultad de Medicina Veterinaria y Zootecnia  de la Universidad Autonoma del Estado de Mexico (UAEM).

Experiencia laboral en producción de vacunas y medios diagnosticos veterinarios. Empresa Productora LABIOFAM, La Habana, Cuba (2011-2018).

Participación en Congresos como: Congreso Panamericano de Ciencias Veterinarias, PANVET del 2014 y 2016. Congreso Biotecnología Habana. Cuba, Diciembre, 2014. Participacion en el 32 Congreso Mundial de Veterinaria. Turquía, Septiembre, 2015. 1er Congreso Bioprocess Cuba 2017, Cuba, Febrero 2017. Certificado de participación como ponente en el XVI Congreso Biotecnología Chiapas 2017, México, Mayo 2017. Certificado de participación en el XXV Congreso Internacional ALPZA 2017, Cuba, Mayo 2017.Ponencia en el 4to Encuentro Internacional de Ciencias Farmacéuticas y Alimentarias ECFA 2017.Ponencia en el Simposium de Zoonosis. Centro Universitario UAEM Amecameca. 2019

Entrenamiento en tecnicas moleculares: Electroforesis, secuenciación de ADN, PCR, Southern, Northern y Western blotting. Clonaje y expresión de genes foráneos en vectores de bacterias y levaduras. Purificación de plásmidos a escala analítica y masiva.Obtención de células electro-competentes y quimio-competentes para la transformación genética. Obtención de proteínas heterólogas mediante fermentación en condiciones controladas.Obtención de Bancos de Células Maestros y Bancos de Células de Trabajo para la conservación de las líneas celulares de producción. Produccion de vacunas y medios diagnosticos. 

 

 

 

Roberto Montes de Oca Jiménez, Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México.

Director del Centro Universitario AMECAMECA. Universidad Autonoma del Estado de Mexico.

Jorge Antonio Varela Guerrero, Universidad Autónoma del Estado de México. Centro de Investigación y Estudios Avanzados en Salud Animal (CIESA). Facultad de Medicina Veterinaria y Zootecnia. km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, México.

Facultad de Medicina Veterinaria y Zootecnia. Departamento de Coordinación de Docencia de la Licenciatura

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Publicado

11.02.2022

Cómo citar

Rodríguez Domínguez, M. C., Montes de Oca Jiménez, R., & Varela Guerrero, J. A. (2022). Linfadenitis caseosa: factores de virulencia, patogénesis y vacunas. Revisión. Revista Mexicana De Ciencias Pecuarias, 12(4), 1221–1249. https://doi.org/10.22319/rmcp.v12i4.5699
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