Estrés oxidativo y el uso de antioxidantes en la producción in vitro de embriones mamíferos. Revisión
DOI:
https://doi.org/10.22319/rmcp.v10i2.4652Palabras clave:
Antioxidantes, Especies reactivas de oxígeno, Estrés oxidativo, Cultivo in vitro, Desarrollo embrionarioResumen
La producción de embriones in vitro es una de las biotecnologías de la reproducción animal que ha presentado mayor desarrollo en las últimas dos décadas; sin embargo, los resultados exitosos en estos procedimientos dependen de múltiples factores, entre ellos la presencia de especies reactivas de oxígeno, debido a que el proceso de fertilización in vitro y la manipulación de los gametos y embriones expone a las células a factores endógenos y exógenos que pueden afectar los mecanismos de defensa antioxidante y por consiguiente la calidad de los gametos y embriones. En esta revisión se discutirán algunas fuentes de especies reactivas de oxígeno, el uso de antioxidantes enzimáticos, no enzimáticos y polifenólicos para disminuir el estrés oxidativo en los procesos de producción in vitro de embriones, y su efecto sobre la calidad de los oocitos y embriones, la expresión génica y su competencia para el desarrollo embrionario.Descargas
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