Kisspeptina en becerras prepúberes: I. Influencia de la edad en la respuesta de LH, FSH y GH a kisspeptina-10 y su asociación con IGF-I, leptina y estradiol
DOI:
https://doi.org/10.22319/rmcp.v8i4.4644Palabras clave:
Kisspeptina, Becerras prepúberes, LH, FSH, GH.Resumen
El objetivo fue evaluar la respuesta de LH, FSH y GH a kisspeptina-10 (KISS) en becerras prepúberes de distintas edades, y su asociación con IGF-I, E2 y leptina circulantes. A 21 becerras de 4, 7 y 11 meses de edad se les aplicó una inyección i.v. de 5 µg de KISS/kg de peso. En suero obtenido de la yugular (cada 15 min, 4 h pre hasta 4 h post-KISS) se cuantificó LH, FSH y GH. En nueve muestras (tres pre y seis post-KISS) se determinó IGF-I, leptina y estradiol (E2). En todas las becerras aumentó la LH post-KISS, con un valor máximo (6.1±1.3a, 7.2±1.3a, 11.6+1.3b ng/ml) y duración de respuesta (64.3±20a, 92±20b, 132.9+20c min) que aumentó (P<0.05) con la edad. Para FSH, 71.4, 100 y 100 % de las becerras de 4, 7 y 11 meses respondieron a KISS-10; situación que para GH fue 71.4, 85.7 y 100 %, respectivamente. La magnitud de la respuesta de FSH y GH a KISS fue similar entre edades. Las becerras de 11 meses tuvieron las máximas concentraciones de IGF-I y E2 y las menores de leptina. Se concluye que KISS-10 evoca un aumento de LH en becerras de 4 a 11 meses, cuya magnitud de respuesta se asocia con la edad, con el incremento en sangre periférica de IGF-I y E2 y con la disminución de leptina sérica; en contraste, la respuesta de GH y FSH a KISS-10 no es afectada por la edad ni por las variaciones en IGF-I, E2 y leptina.
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Byerley DJ, Staigmiller RB, Berardinelli JG, Short RE. Pregnancy rates of beef heifers bred either on pubertal or third estrus. J Anim Sci 1997;65:645-650.
Lin CY, McAllister AJ, Batra TR, Lee AJ, Roy GL, Vesely JA, et al. Effects of early and late breeding of heifers on multiple lactation performance of dairy cows. J Dairy Sci 1988;71:2735-2743.
Perry GA. Harnessing basic knowledge of factors controlling puberty to improve synchronization of estrus and fertility of heifers. J Anim Sci 2012;90:1172-1182.
Mukasa-Mugerwa E. A review of reproductive performance of female Bos indicus (Zebu) cattle. FAO-ILCA Monograph No. 6, Chapter 4 Measures of reproductive performance 1989.
http://www.fao.org/Wairdocs/ILRI/x5442E/x5442e06.htm#4.1%20age%20at%20first%20calving. Consultado 17 Mar, 2016.
Hoffman PC. Optimum body size of Holstein replacement heifers. J Anim Sci 1997;75:836-845.
Deresz F, Jaume CM, de Carvalho MR, González CA. The effect of body weight at calving on milk production and reproductive performance of FriesianxZebu heifers. Animal Production 1987;45:325-333.
Terasawa EI, Fernandez DL. Neurobiological mechanisms of the onset of puberty in primates. Endocrine Rev 2001;22:111-151.
Ebling FJP. The neuroendocrine timing of puberty. Reproduction 2005;129:675-683.
Abbara A, Radnasabapathy R, Jayasena CN, Dhillo W. The effects of kisspeptin on gonadotropin release in non-human mammals. Chapter 4. In: Kauffman AS, Smith JT. Kisspeptine signaling in reproductive biology. New York, Heidelberg, Dordrecht, London: Springer; 2013:429-434.
Smith JT. The role of kisspeptine and gonadotrophin inhibitory hormone in the seasonal regulation of reproduction in sheep. Domest Anim Endocrinol 2012;43:75-84.
Mead E, Maguire JJ, Kuc RE, Davenport AP. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. British J Pharmacol 2007;151:1143-1153.
Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol 2012;8:40-53.
Lents CA, Heidorn NL, Barb CR, Ford JJ. Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts. Reproduction 2008;135:879-887.
Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, et al. Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol Cell Endo 2006;257:75–83.
Kadokawa H, Matsui M, Hayashi K, Matsunaga N, Kawashima C, Shimizu T, et al. Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers. J Endocrinol 2008;196:331-334.
Ezzat AA, Saito H, Sawada T, Yaegashi T, Yamashita T, Hirata TI, et al. Characteristics of the stimulatory effect of Kisspeptin-10 on the secretion of luteinizing hormone, follicle-stimulating hormone and growth hormone in prepubertal male and female cattle. J Reprod Dev 2009;55:650-654.
Jones EJ, Armstrong JD, Harvey RW. Changes in metabolites, metabolic hormones, and luteinizing hormone before puberty in Angus, Bradford, Charolais and Simmental heifers. J Anim Sci 1991;60:1607-1615.
Archbold H, Shalloo L, Kennedy E, Pierce KM, Buckley F. Influence of age, body weight and body condition score before mating start date on the pubertal rate of maiden Holstein–Friesian heifers and implications for subsequent cow performance and profitability. Animal 2012;6(07):1143-1151.
Yelich JV, Wettemann RP, Marston TT, Spicer LJ. Luteinizing hormone, growth hormone, insulin-like growth factor-I, insulin and metabolites before puberty in heifers fed to gain at two rates. Domest Anim Endocrinol 1996;13:325-338.
Velazquez MA, Spicer LJ, Wathes DC. The role of insulin-like growth factor-I (IGF-I) in female bovine reproduction. Domest Anim Endocrinol 2008;35:325-342.
Garcia MR, Amstalden M, Williams SW, Stanko RL, Morrison CD, Keisler DH, et al. Serum leptin and its adipose gene expression during pubertal development, the estrous cycle, and different seasons in cattle. J Anim Sci 2002;80:2158-2167.
León HV, Hernández-Cerón J, DH, Gutierrez, CG. Plasma concentrations of leptin, insulin-like growth factor-I, and insulin in relation to changes in body condition score in heifers. J Anim Sci 2004;82:445-451.
Zulu VCh, Nakao T, Sawamuka Y. Insulin-growth like factor I as a possible hormonal mediator nutritional regulation of reproduction in cattle. J Vet Med Sci 2002;64(8):657-665.
Zieba DA, Amstalden M, Maciel MN, Keisler DH, Raver N, Gertler A, Williams GL. Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent. Experimental Biol Med 2003;228:325-333.
Gasser CL, Burke CL, Mussard ML, Behlke EJ, Grum DE, Kinder JE, Day ML. Induction of precocious puberty in heifers II: Advanced ovarian follicular development. J Anim Sci 2006;84:2042–2049.
Gasser CL, Grum DE, Mussard ML, Fluharty FL, Kinder JE, Day ML. Induction of precocious pubertyin heifers I: Enhanced secretion of luteinizing hormone. J Anim Sci 2006;84:2035–2041.
Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G. A body condition scoring chart for Holstein dairy cows. J Dairy Sci 1989;72:68-78.
England BG, Niswender GD, Midgley AR. Radioimmunoassay of estradiol-17β without chromatography. J Clin Endocrinol Metab 1974;38(1):42-50.
Nett TM, Akbar AM, Phemister RD, Holst PA, Reichert JR, Niswender GD. Levels of luteinizing hormone, estradiol and progesterone in serum during the estrous cycle and pregnancy in the Beagle bitch. Proc Soc Exp Biol Med 1975;148:134-139.
L’Hermite M, Niswender GD, Reichert Jr, LE, Midgley Jr, AR. Serum follicle-stimulating hormone in sheep as measured by radioimmunoassay. Biol Reprod 1972;6:325-332.
Powell M, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci 1995;73:1901-1905.
SAS. Statistical Analysis System Institute. 2002 Inc, Cary, NC, USA.
Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, et al. Effects of Kiss-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 2005;146:1689-1697.
Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sánchez-Criado JE, et al. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of kiss-1 peptide. Endocrinol 2004;145:4565-4574.
Whitlock BK, Daniel JA, Wilborn RR, Rodning SP, Maxwell HS, Steele BP, Sartin JL. Interaction of estrogen and progesterone on kisspeptin-10-stimulated luteinizing hormone and growth hormone in ovariectomized cows. Neuroendocrinology 2008;88:212-215.
Clarkson J, Boon WC, Simpson RE, Herbison AE. Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinol 2009;150:3214-3220.
Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ. Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinol 2008;149:1951-1959.
DiVall SA, Williams TR, Carver SE, Koch L, Brüning JC, Kahn CR, Wondisford F, Radovick S, Wolfe A. Divergent roles of growth factors in the GnRH regulation of puberty in mice. J Clin Invest 2010;120:2900-2909.
Santos ER, Calderón RRC, Vera ARH, Perera-Marín G, Arreguín AJA, Nett TM, et al. Hormona luteinizante y actividad ovárica en respuesta a kisspeptina-10 y su asociación con IGF-1 y leptina en becerras pre-púberes. Rev Mex Cienc Pecu 2014;5(2):181-200.
Hiney J.K, Srivastava V, Nyberg CL Ojeda SR, Dees WL. Insulin-like growth factor-1 (IGF-1) of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinol 1996;137:3717-3727.
Adam CL, Gadd TS, Findlay PA, Wathes DC. IGF-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland. J Endocrinol 2000;166:247-254.
Reinhardt RR, Bondy CA. Insulin-like growth factors cross the blood brain barrier. Endocrinol 1994;135:1753-1761.
Hiney JK, Srivastava V, Dearth RK, Dees WL. Influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion. Brain Res 2004;1013:91-97.
Nagatani S, Guthikonda P, Foster DL. Appearance of a nocturnal peak of leptin secretion in the pubertal rat. Hormones Behav 2000;37:345-352.
Martos-Moreno GA, Barrios V, Soriano-Guillén L, Argente J. Relationship between adiponectin levels, acylated ghrelin levels, and short-term body mass index changes in children with diabetes mellitus type 1 at diagnosis and after insulin therapy. Eur J Endocrinol 2006;155:757-761.
Garcia MR, Amstalden M, Morrison CD, Keisler DH, Williams GL. Age at puberty, total fat and conjugated linoleic acid content of carcass, and circulating metabolic hormones in beef heifers fed a diet high in linoleic acid beginning at four months of age. J Anim Sci 2003;81:261-268.
Maciel MN, Zieba DA, Amstalden M, Keisler DH, Neves JP, Williams GL. Chronic administration of recombinant ovine leptin in growing beef heifers: Effects on secretion of LH, metabolic hormones, and timing of puberty. J Anim Sci 2004;82:2930-2936.
Zieba DA, Amstalden M, Williams GL. Regulatory roles of leptin in reproduction and metabolism: A comparative review. Domest Anim Endocrinol 2005;29:166-185.
Iqbal J, Pompolo S, Considine RV, Clarke IJ. Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine pituitary gland. Endocrinol 2000;141:1515-1520.
Dyer CJ, Simmons JM, Matteri RL, Keisler DH. Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes. Domest Anim Endocrinol 1997;14:119-128.
Coss D, Mellon PL, Thackray VG. A FoxL in the Smad house activin regulation of FSH. Trends Endocrinol Metab 2010;21:562-568.
Phillips JD. Activins, inhibins and follistatins in the large domestic species. Domest Anim Endocrinol 2005;28:1-16.
Thackray VG, Mellon PL, Coss D. Hormones in synergy: Regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol 2010;314:92-203.
Foster CM, Phillips DJ, Wyman T, Evans LW, Groome NP, Padmanabhan V. Changes in serum inhibin, activin and follistatin concentrations during puberty in girls. Human Reprod 2000;15(5):1052-1057.
Rogol AD, Roemmich JN, Clark PA. Growth at Puberty. J Adolesc Health 2002;31:192-200.
Cheung CC, Thornton JE, Nurani SD, Clifton DK, Steiner RA. A reassessment of leptin's role in triggering the onset of puberty in the rat and mouse. Neuroendocrinol 2001;74:12-21.
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